TitleConstitutivelyactiveABLfamilykinases,TEL/ABLandTEL/ARG,harbordistinctleukemogenicactivitiesinvivoAbstractABL(ABL1)andARG(ABL2)arehighlyhomologoustoeachotherinoveralldomainstructureandamino-acidsequence,withtheexceptionoftheirCtermini.AswithABL,translocationsthatfuseARGtoETV6/TELhavebeenidentifiedinpatientswithleukemia.ToassesstheinvivoleukemogenicactivityofconstitutivelyactiveABLandARG,wegeneratedabonemarrow(BM)transplantationmodelusingthechimericformsTEL/ABLandTEL/ARG,whichhave







































北京中科白癜风医学研究院
北京请问哪个医院治疗白癜风效果最好呢